PrimePCR™ SYBR® Green Assay: OAZ1, Cow

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

Real-time PCR primer assay designed for SYBR® Green gene expression analysis.

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Assay Information

Technology:   qPCR
Assay Type:   SYBR® Green
Application:   Gene Expression
Unique Assay ID:   qBtaCED0010725
Assay Design:   Exonic
Chromosome Location:   7:22578515-22579047question
Amplicon Length:   99
Splice Variants Targeted:   ENSBTAT00000024656

Gene Information

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]

Gene Symbol:   OAZ1
Gene Name:   Bos taurus ornithine decarboxylase antizyme 1 (OAZ1), mRNA.
Aliases:   Not Available
RefSeq:   NM_001127243
Ensembl:   ENSBTAG00000018522
Entrez:   506973
UniGene:   Bt.3694
Chromosome Mapping:   7

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