PrimePCR™ ddPCR™ Expression Probe Assay: Abcc5, Mouse

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qMmuCEP0054633; exonic

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dMmuCPE5096382
Chromosome Location:   16:20422388-20426249question
Amplicon Length:   70

Gene Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1 MDR/TAP MRP ALD OABP GCN20 White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs 6-mercatopurine and thioguanine and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   Abcc5
Gene Name:   ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Aliases:   2900011L11Rik, AI132311, Abcc5a, Abcc5b, Mrp5
RefSeq:   NC_000082.6 NT_039624.8
Ensembl:   ENSMUSG00000022822
Entrez:   27416
UniGene:   Mm.20845
Chromosome Mapping:   16 A3|16 14.0 cM

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