PrimePCR™ ddPCR™ Expression EvaGreen® Assay: FIP1L1, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0057207; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5013772
Chromosome Location:   4:54248488-54255976question
Amplicon Length:   90

Gene Information

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene the homolog of yeast Fip1 (factor interacting with PAP) binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome recently reclassified as chronic eosinophilic leukemia (CEL) is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq Oct 2008]

Gene Symbol:   FIP1L1
Gene Name:   FIP1 like 1 (S. cerevisiae)
Aliases:   DKFZp586K0717, FLJ33619, Rhe, hFip1
RefSeq:   NC_000004.11 NT_022853.15 NG_008644.1
Ensembl:   ENSG00000145216
Entrez:   81608
UniGene:   Hs.624245
Chromosome Mapping:   4q12

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