PrimePCR™ ddPCR™ Expression EvaGreen® Assay: TOP2A, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0057177; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5013745
Chromosome Location:   17:38569760-38569864question
Amplicon Length:   75

Gene Information

This gene encodes a DNA topoisomerase an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation chromatid separation and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form alpha is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq Jul 2010]

Gene Symbol:   TOP2A
Gene Name:   topoisomerase (DNA) II alpha 170kDa
Aliases:   TOP2, TP2A
RefSeq:   NC_000017.10 NG_027678.1 NT_010783.15
Ensembl:   ENSG00000131747
Entrez:   7153
UniGene:   Hs.156346
Chromosome Mapping:   17q21-q22

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