PrimePCR™ ddPCR™ Expression EvaGreen® Assay: ELANE, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0048210; exonic

List Price:    $138.00
Your Price:   Log In

Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5012464
Chromosome Location:   19:856066-856241question
Amplicon Length:   146

Gene Information

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes called azurophil granules as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members azurocidin 1 and proteinase 3 genes at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq May 2009]

Gene Symbol:   ELANE
Gene Name:   elastase, neutrophil expressed
Aliases:   ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
RefSeq:   NC_000019.9 NG_007274.1 NG_009627.1 NT_011255.14
Ensembl:   ENSG00000197561
Entrez:   1991
UniGene:   Hs.99863
Chromosome Mapping:   19p13.3

Number Description Download