PrimePCR™ ddPCR™ Expression EvaGreen® Assay: HSD11B2, Human

PrimePCR Primer Assays for Real-Time PCR oligo primer pair tube for SYBR Green gene expression

ddPCR Evagreen assay for gene expression analysis. EvaGreen assays consist of unlabeled PCR primer.

Info:   EG; Same primer pair as used in qPCR assay qHsaCED0047172; exonic

List Price:    $138.00
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Assay Information

Technology:   ddPCR
Assay Type:   EvaGreen
Application:   Gene Expression
Unique Assay ID:   dHsaEG5011529
Chromosome Location:   16:67471230-67471365question
Amplicon Length:   106

Gene Information

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme encoded by this gene has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor such as the placenta and testis it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq Feb 2010]

Gene Symbol:   HSD11B2
Gene Name:   hydroxysteroid (11-beta) dehydrogenase 2
Aliases:   AME, AME1, HSD11K, HSD2, SDR9C3
RefSeq:   NC_000016.9 NG_011482.1 NG_016549.1 NT_010498.15
Ensembl:   ENSG00000176387
Entrez:   3291
UniGene:   Hs.1376
Chromosome Mapping:   16q22

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