PrimePCR™ ddPCR™ Expression Probe Assay: PPM1E, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0030412; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5054119
Chromosome Location:   17:57050248-57057447question
Amplicon Length:   122

Gene Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1) a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42). [provided by RefSeq Jul 2008]

Gene Symbol:   PPM1E
Gene Name:   protein phosphatase, Mg2+/Mn2+ dependent, 1E
Aliases:   CaMKP-N, DKFZp781F1422, KIAA1072, POPX1, PP2CH
RefSeq:   NC_000017.10 NG_009298.1 NT_010783.15
Ensembl:   ENSG00000175175
Entrez:   22843
UniGene:   Hs.245044
Chromosome Mapping:   17q22

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