PrimePCR™ ddPCR™ Expression Probe Assay: NLRP8, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0030155; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053637
Chromosome Location:   19:56467366-56473505question
Amplicon Length:   144

Gene Information

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs such as NALP8 have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD) followed by a NACHT domain a NACHT-associated domain (NAD) and a C-terminal leucine-rich repeat (LRR) region. The long NALP NALP1 (MIM 606636) also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g. CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al. 2003 [PubMed 12563287]).[supplied by OMIM Mar 2008]

Gene Symbol:   NLRP8
Gene Name:   NLR family, pyrin domain containing 8
Aliases:   CLR19.2, NALP8, NOD16, PAN4
RefSeq:   NC_000019.9 NT_011109.16
Ensembl:   ENSG00000179709
Entrez:   126205
UniGene:   Hs.446925
Chromosome Mapping:   19q13.43

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