PrimePCR™ ddPCR™ Expression Probe Assay: ACO1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029848; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053063
Chromosome Location:   9:32420990-32424549question
Amplicon Length:   109

Gene Information

Aconitase 1 also known as iron regulatory element binding protein 1 (IREB1) is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity and hence grouped with the aconitase family of enzymes. [provided by RefSeq Jul 2008]

Gene Symbol:   ACO1
Gene Name:   aconitase 1, soluble
RefSeq:   NC_000009.11 NT_008413.18
Ensembl:   ENSG00000122729
Entrez:   48
UniGene:   Hs.567229
Chromosome Mapping:   9p22-q32,9p21.1

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