PrimePCR™ ddPCR™ Expression Probe Assay: DMP1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029841; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053051
Chromosome Location:   4:88571459-88577670question
Amplicon Length:   95

Gene Information

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein which is critical for proper mineralization of bone and dentin is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains multiple phosphorylation sites a functional arg-gly-asp cell attachment sequence and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   DMP1
Gene Name:   dentin matrix acidic phosphoprotein 1
Aliases:   ARHP, ARHR, DMP-1
RefSeq:   NC_000004.11 NT_016354.19 NG_008988.1
Ensembl:   ENSG00000152592
Entrez:   1758
UniGene:   Hs.652366
Chromosome Mapping:   4q21

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