PrimePCR™ ddPCR™ Expression Probe Assay: KPNB1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029828; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5053028
Chromosome Location:   17:45745661-45747085question
Amplicon Length:   128

Gene Information

Nucleocytoplasmic transport a signal- and energy-dependent process takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq Jul 2008]

Gene Symbol:   KPNB1
Gene Name:   karyopherin (importin) beta 1
Aliases:   IMB1, IPO1, IPOB, Impnb, MGC2155, MGC2156, MGC2157, NTF97
RefSeq:   NC_000017.10 NT_010783.15
Ensembl:   ENSG00000108424
Entrez:   3837
UniGene:   Hs.532793
Chromosome Mapping:   17q21.32

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