PrimePCR™ ddPCR™ Expression Probe Assay: PTPN1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029758; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052896
Chromosome Location:   20:49197897-49199275question
Amplicon Length:   118

Gene Information

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitotic cycle and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase as well as JAK2 and TYK2 kinases which implicated the role of this PTP in cell growth control and cell response to interferon stimulation. [provided by RefSeq Jul 2008]

Gene Symbol:   PTPN1
Gene Name:   protein tyrosine phosphatase, non-receptor type 1
Aliases:   PTP1B
RefSeq:   NC_000020.10 NG_012119.1 NT_011362.10
Ensembl:   ENSG00000196396
Entrez:   5770
UniGene:   Hs.417549
Chromosome Mapping:   20q13.1-q13.2

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