PrimePCR™ ddPCR™ Expression Probe Assay: CCNE1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029726; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052834
Chromosome Location:   19:30313453-30314623question
Amplicon Length:   90

Gene Information

The protein encoded by this gene belongs to the highly conserved cyclin family whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2 whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors which results in chromosome instability and thus may contribute to tumorigenesis. This protein was found to associate with and be involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus) which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene which encode distinct isoforms have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq Jul 2008]

Gene Symbol:   CCNE1
Gene Name:   cyclin E1
Aliases:   CCNE
RefSeq:   NC_000019.9 NT_011109.16
Ensembl:   ENSG00000105173
Entrez:   898
UniGene:   Hs.244723
Chromosome Mapping:   19q12

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