PrimePCR™ ddPCR™ Expression Probe Assay: INPP5D, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029573; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052573
Chromosome Location:   2:234070384-234072399question
Amplicon Length:   106

Gene Information

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain an inositol phosphatase domain and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane the protein hydrolyzes the 5' phosphate from phosphatidylinositol (345)-trisphosphate and inositol-1345-tetrakisphosphate thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   INPP5D
Gene Name:   inositol polyphosphate-5-phosphatase, 145kDa
Aliases:   MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
RefSeq:   NC_000002.11 NT_005120.16 NT_005403.17
Ensembl:   ENSG00000168918
Entrez:   3635
UniGene:   Hs.262886
Chromosome Mapping:   2q37.1

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