PrimePCR™ ddPCR™ Expression Probe Assay: LMNB1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029571; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052568
Chromosome Location:   5:126145954-126147514question
Amplicon Length:   109

Gene Information

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability chromatin structure and gene expression. Vertebrate lamins consist of two types A and B. This gene encodes one of the two B type proteins B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq Oct 2010]

Gene Symbol:   LMNB1
Gene Name:   lamin B1
Aliases:   ADLD, LMN, LMN2, LMNB, MGC111419
RefSeq:   NC_000005.9 NG_008360.2 NT_034772.6
Ensembl:   ENSG00000113368
Entrez:   4001
UniGene:   Hs.89497
Chromosome Mapping:   5q23.2

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