PrimePCR™ ddPCR™ Expression Probe Assay: ZNF384, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029556; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052546
Chromosome Location:   12:6788332-6797379question
Amplicon Length:   102

Gene Information

This gene encodes a C2H2-type zinc finger protein which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1 MMP3 MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene EWSR1 on chromosome 22 or with the TAF15 gene on chromosome 17 or with the TCF3 (E2A) gene on chromosome 19 have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq Apr 2011]

Gene Symbol:   ZNF384
Gene Name:   zinc finger protein 384
Aliases:   CAGH1, CAGH1A, CIZ, ERDA2, FLJ59043, NMP4, NP, TNRC1
RefSeq:   NC_000012.11 NT_009759.16
Ensembl:   ENSG00000126746
Entrez:   171017
UniGene:   Hs.103315
Chromosome Mapping:   12p12

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