PrimePCR™ ddPCR™ Expression Probe Assay: MBD5, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029530; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052499
Chromosome Location:   2:149227923-149240715question
Amplicon Length:   115

Gene Information

This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif) which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly intellectual disabilities severe speech impairment and seizures. Alternatively spliced transcript variants have been found but their full-length nature is not determined. [provided by RefSeq Mar 2010]

Gene Symbol:   MBD5
Gene Name:   methyl-CpG binding domain protein 5
Aliases:   FLJ11113, FLJ30517, KIAA1461, MRD1
RefSeq:   NC_000002.11 NG_017003.1 NT_022135.16
Ensembl:   ENSG00000204406
Entrez:   55777
UniGene:   Hs.458312
Chromosome Mapping:   2q23.1

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