PrimePCR™ ddPCR™ Expression Probe Assay: MKNK2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0029303; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5052113
Chromosome Location:   19:2043557-2046254question
Amplicon Length:   65

Gene Information

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E) thus playing important roles in the initiation of mRNA translation oncogenic transformation and malignant cell proliferation. In addition to eIF4E this protein also interacts with von Hippel-Lindau tumor suppressor (VHL) ring-box 1 (Rbx1) and Cullin2 (Cul2) which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation and in subcellular localization. [provided by RefSeq Aug 2011]

Gene Symbol:   MKNK2
Gene Name:   MAP kinase interacting serine/threonine kinase 2
Aliases:   GPRK7, MNK2
RefSeq:   NC_000019.9 NT_011255.14
Ensembl:   ENSG00000099875
Entrez:   2872
UniGene:   Hs.515032
Chromosome Mapping:   19p13.3

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