PrimePCR™ ddPCR™ Expression Probe Assay: UCP2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0029025; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5051672
Chromosome Location:   11:73686593-73687774question
Amplicon Length:   144

Gene Information

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq Jul 2008]

Gene Symbol:   UCP2
Gene Name:   uncoupling protein 2 (mitochondrial, proton carrier)
Aliases:   BMIQ4, SLC25A8, UCPH
RefSeq:   NC_000011.9 NG_011478.1 NT_167190.1
Ensembl:   ENSG00000175567
Entrez:   7351
UniGene:   Hs.80658
Chromosome Mapping:   11q13

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