PrimePCR™ ddPCR™ Expression Probe Assay: EBP, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0028902; Intron-spanning

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5051470
Chromosome Location:   X:48382375-48385569question
Amplicon Length:   120

Gene Information

The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq Jul 2008]

Gene Symbol:   EBP
Gene Name:   emopamil binding protein (sterol isomerase)
Aliases:   CDPX2, CHO2, CPX, CPXD
RefSeq:   NC_000023.10 NG_007452.1 NG_009278.1 NT_079573.4
Ensembl:   ENSG00000147155
Entrez:   10682
UniGene:   Hs.30619
Chromosome Mapping:   Xp11.23-p11.22

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