PrimePCR™ ddPCR™ Expression Probe Assay: ZP3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027441; Intron-spanning

Fluorophore:   FAM
List Price:    $213.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048964
Chromosome Location:   7:76058883-76062328question
Amplicon Length:   123

Gene Information

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence a conserved ZP domain a C-terminal consensus furin cleavage site and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3 including the above described variation and maps closely to this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   ZP3
Gene Name:   zona pellucida glycoprotein 3 (sperm receptor)
Aliases:   ZP3A, ZP3B, ZPC, Zp-3
RefSeq:   NC_000007.13 NT_007933.15
Ensembl:   ENSG00000188372
Entrez:   7784
UniGene:   Hs.656137
Chromosome Mapping:   7q11.23

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