PrimePCR™ ddPCR™ Expression Probe Assay: TERT, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027108; Intron-spanning

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048434
Chromosome Location:   5:1258726-1264523question
Amplicon Length:   150

Gene Information

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity encoded by this gene and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq Jul 2008]

Gene Symbol:   TERT
Gene Name:   telomerase reverse transcriptase
Aliases:   EST2, TCS1, TP2, TRT, hEST2
RefSeq:   NC_000005.9 NT_006576.16 NG_009265.1
Ensembl:   ENSG00000164362
Entrez:   7015
UniGene:   Hs.492203
Chromosome Mapping:   5p15.33

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