PrimePCR™ ddPCR™ Expression Probe Assay: MAP3K8, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCIP0027090; Intron-spanning

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048400
Chromosome Location:   10:30747103-30748258question
Amplicon Length:   108

Gene Information

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq Sep 2011]

Gene Symbol:   MAP3K8
Gene Name:   mitogen-activated protein kinase kinase kinase 8
Aliases:   COT, EST, ESTF, FLJ10486, MEKK8, TPL2, Tpl-2, c-COT
RefSeq:   NC_000010.10 NT_008705.16
Ensembl:   ENSG00000107968
Entrez:   1326
UniGene:   Hs.432453
Chromosome Mapping:   10p11.23

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