PrimePCR™ ddPCR™ Expression Probe Assay: JAK1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026945; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5048151
Chromosome Location:   1:65311241-65312378question
Amplicon Length:   100

Gene Information

Janus kinase 1 (JAK1) is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway and between JAK1 and JAK2 in the interferon-gamma pathway may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription or STATs. [provided by RefSeq Jul 2008]

Gene Symbol:   JAK1
Gene Name:   Janus kinase 1
Aliases:   JAK1A, JAK1B, JTK3
RefSeq:   NC_000001.10 NG_023402.1 NT_032977.9
Ensembl:   ENSG00000162434
Entrez:   3716
UniGene:   Hs.207538
Chromosome Mapping:   1p32.3-p31.3

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