PrimePCR™ ddPCR™ Expression Probe Assay: CHRNA4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026313; Intron-spanning

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5047043
Chromosome Location:   20:61978153-61981052question
Amplicon Length:   81

Gene Information

This gene encodes a nicotinic acetylcholine receptor which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq Feb 2012]

Gene Symbol:   CHRNA4
Gene Name:   cholinergic receptor, nicotinic, alpha 4
Aliases:   BFNC, EBN, EBN1, FLJ95812, NACHR, NACHRA4, NACRA4
RefSeq:   NC_000020.10 NG_011931.1 NT_011333.6
Ensembl:   ENSG00000101204
Entrez:   1137
UniGene:   Hs.10734
Chromosome Mapping:   20q13.2-q13.3

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