PrimePCR™ ddPCR™ Expression Probe Assay: FBXW4, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCIP0026275; Intron-spanning

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5046971
Chromosome Location:   10:103433369-103436180question
Amplicon Length:   115

Gene Information

This gene is a member of the F-box/WD-40 gene family which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq Jul 2008]

Gene Symbol:   FBXW4
Gene Name:   F-box and WD repeat domain containing 4
Aliases:   DAC, FBW4, FBWD4, SHFM3, SHSF3
RefSeq:   NC_000010.10 NG_008091.1 NT_030059.13
Ensembl:   ENSG00000107829
Entrez:   6468
UniGene:   Hs.500822
Chromosome Mapping:   10q24

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