PrimePCR™ ddPCR™ Expression Probe Assay: DAG1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0054239; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5041022
Chromosome Location:   3:49548089-49548186question
Amplicon Length:   68

Gene Information

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq Apr 2010]

Gene Symbol:   DAG1
Gene Name:   dystroglycan 1 (dystrophin-associated glycoprotein 1)
Aliases:   156DAG, A3a, AGRNR, DAG
RefSeq:   NC_000003.11 NG_013230.2 NT_022517.18
Ensembl:   ENSG00000173402
Entrez:   1605
UniGene:   Hs.76111
Chromosome Mapping:   3p21

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