PrimePCR™ ddPCR™ Expression Probe Assay: GSTM4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0053835; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5040321
Chromosome Location:   1:110198749-110198860question
Amplicon Length:   82

Gene Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha kappa mu omega pi sigma theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds including carcinogens therapeutic drugs environmental toxins and products of oxidative stress by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains as well as in tissue expression patterns to accommodate an increasing number of foreign compounds. Multiple transcript variants each encoding a distinct protein isoform have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   GSTM4
Gene Name:   glutathione S-transferase mu 4
Aliases:   GSTM4-4, GTM4, MGC131945, MGC9247
RefSeq:   NC_000001.10 NT_032977.9
Ensembl:   ENSG00000168765
Entrez:   2948
UniGene:   Hs.348387
Chromosome Mapping:   1p13.3

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