PrimePCR™ ddPCR™ Expression Probe Assay: WRN, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0053562; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039819
Chromosome Location:   8:31030650-31030782question
Amplicon Length:   103

Gene Information

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism including transcription replication recombination and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome an autosomal recessive disorder characterized by premature aging. [provided by RefSeq Jul 2008]

Gene Symbol:   WRN
Gene Name:   Werner syndrome, RecQ helicase-like
Aliases:   DKFZp686C2056, RECQ3, RECQL2, RECQL3
RefSeq:   NC_000008.10 NG_008870.1 NT_167187.1
Ensembl:   ENSG00000165392
Entrez:   7486
UniGene:   Hs.632050
Chromosome Mapping:   8p12

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