PrimePCR™ ddPCR™ Expression Probe Assay: CYP3A4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0053177; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5039112
Chromosome Location:   7:99355515-99355727question
Amplicon Length:   183

Gene Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today including acetaminophen codeine cyclosporin A diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene CYP3A3 was thought to exist; however it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Feb 2011]

Gene Symbol:   CYP3A4
Gene Name:   cytochrome P450, family 3, subfamily A, polypeptide 4
Aliases:   CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, MGC126680, NF-25, P450C3, P450PCN1
RefSeq:   NC_000007.13 NG_000004.3 NG_008421.1 NT_007933.15
Ensembl:   ENSG00000160868
Entrez:   1576
UniGene:   Hs.728751
Chromosome Mapping:   7q21.1

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