PrimePCR™ ddPCR™ Expression Probe Assay: NR1I2, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0052491; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5037898
Chromosome Location:   3:119536593-119536718question
Amplicon Length:   96

Gene Information

This gene product belongs to the nuclear receptor superfamily members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4 binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4 including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms some of which use non-AUG (CUG) translation initiation codon have been described for this gene. Additional transcript variants exist however they have not been fully characterized. [provided by RefSeq Jul 2008]

Gene Symbol:   NR1I2
Gene Name:   nuclear receptor subfamily 1, group I, member 2
Aliases:   BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
RefSeq:   NC_000003.11 NG_011856.1 NT_005612.16
Ensembl:   ENSG00000144852
Entrez:   8856
UniGene:   Hs.7303
Chromosome Mapping:   3q12-q13.3

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