PrimePCR™ ddPCR™ Expression Probe Assay: APOE, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0051559; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5036246
Chromosome Location:   19:45411108-45411198question
Amplicon Length:   61

Gene Information

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E a main apoprotein of the chylomicron binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia or type III hyperlipoproteinemia (HLP III) in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq Jul 2008]

Gene Symbol:   APOE
Gene Name:   apolipoprotein E
Aliases:   AD2, LDLCQ5, LPG, MGC1571
RefSeq:   NC_000019.9 NG_007084.2 NT_011109.16
Ensembl:   ENSG00000130203
Entrez:   348
UniGene:   Hs.654439
Chromosome Mapping:   19q13.2

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