PrimePCR™ ddPCR™ Expression Probe Assay: FLT3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0051189; exonic

Fluorophore:   HEX
List Price:    $213.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5035583
Chromosome Location:   13:28578014-28578160question
Amplicon Length:   117

Gene Information

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains one transmembrane region and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis proliferation and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq Jul 2008]

Gene Symbol:   FLT3
Gene Name:   fms-related tyrosine kinase 3
Aliases:   CD135, FLK2, STK1
RefSeq:   NC_000013.10 NG_007066.1 NT_024524.14
Ensembl:   ENSG00000122025
Entrez:   2322
UniGene:   Hs.507590
Chromosome Mapping:   13q12

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