PrimePCR™ ddPCR™ Expression Probe Assay: MAPK8IP1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0051174; exonic

Fluorophore:   HEX
List Price:    $213.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5035553
Chromosome Location:   11:45919657-45921704question
Amplicon Length:   71

Gene Information

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1 a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq May 2011]

Gene Symbol:   MAPK8IP1
Gene Name:   mitogen-activated protein kinase 8 interacting protein 1
Aliases:   IB1, JIP-1, JIP1, PRKM8IP
RefSeq:   NC_000011.9 NG_012153.1 NT_009237.18
Ensembl:   ENSG00000121653
Entrez:   9479
UniGene:   Hs.234249
Chromosome Mapping:   11p11.2

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