PrimePCR™ ddPCR™ Expression Probe Assay: CISH, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050823; exonic

Fluorophore:   HEX
List Price:    $213.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5034961
Chromosome Location:   3:50644180-50644315question
Amplicon Length:   106

Gene Information

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS) also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2 IL3 GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Aug 2008]

Gene Symbol:   CISH
Gene Name:   cytokine inducible SH2-containing protein
Aliases:   CIS, CIS-1, G18, SOCS
RefSeq:   NC_000003.11 NG_023194.1 NT_022517.18
Ensembl:   ENSG00000114737
Entrez:   1154
UniGene:   Hs.655334
Chromosome Mapping:   3p21.3

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