PrimePCR™ ddPCR™ Expression Probe Assay: LFNG, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0050383; exonic

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5034178
Chromosome Location:   7:2565399-2565963question
Amplicon Length:   62

Gene Information

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases fringe proteins have a fucose-specific beta-13-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Oct 2009]

Gene Symbol:   LFNG
Gene Name:   LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Aliases:   SCDO3
RefSeq:   NC_000007.13 NT_007819.17 NG_008109.1
Ensembl:   ENSG00000106003
Entrez:   3955
UniGene:   Hs.159142
Chromosome Mapping:   7p22.2

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