PrimePCR™ ddPCR™ Expression Probe Assay: MCM4, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050286; exonic

Fluorophore:   HEX
List Price:    $213.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5034015
Chromosome Location:   8:48874613-48874867question
Amplicon Length:   137

Gene Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2 6 and 7 proteins possesses DNA helicase activity and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq Jul 2008]

Gene Symbol:   MCM4
Gene Name:   minichromosome maintenance complex component 4
Aliases:   CDC21, CDC54, MGC33310, P1-CDC21, hCdc21
RefSeq:   NC_000008.10 NG_023435.1 NT_008183.19
Ensembl:   ENSG00000104738
Entrez:   4173
UniGene:   Hs.460184
Chromosome Mapping:   8q11.2

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