PrimePCR™ ddPCR™ Expression Probe Assay: SPAG1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050274; exonic

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033993
Chromosome Location:   8:101196954-101199445question
Amplicon Length:   76

Gene Information

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility as well as identification of proteins for targeted contraception are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq Jul 2008]

Gene Symbol:   SPAG1
Gene Name:   sperm associated antigen 1
Aliases:   FLJ32920, HSD-3.8, SP75, TPIS
RefSeq:   NC_000008.10 NT_008046.16
Ensembl:   ENSG00000104450
Entrez:   6674
UniGene:   Hs.591866
Chromosome Mapping:   8q22.2

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