PrimePCR™ ddPCR™ Expression Probe Assay: SMAD7, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050142; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033753
Chromosome Location:   18:46448096-46448245question
Amplicon Length:   120

Gene Information

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF-beta receptor type-1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq Jun 2010]

Gene Symbol:   SMAD7
Gene Name:   SMAD family member 7
Aliases:   CRCS3, FLJ16482, MADH7, MADH8
RefSeq:   NC_000018.9 NT_010966.14 NG_023330.1
Ensembl:   ENSG00000101665
Entrez:   4092
UniGene:   Hs.465087
Chromosome Mapping:   18q21.1

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