PrimePCR™ ddPCR™ Expression Probe Assay: VRK1, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050080; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033635
Chromosome Location:   14:97326903-97327050question
Amplicon Length:   118

Gene Information

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells such as those in testis thymus fetal liver and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and in vitro to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene therefore may regulate cell proliferation. This protein also phosphorylates histone casein and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq Jul 2008]

Gene Symbol:   VRK1
Gene Name:   vaccinia related kinase 1
Aliases:   MGC117401, MGC138280, MGC142070, PCH1
RefSeq:   NC_000014.8 NG_016293.1 NT_026437.12
Ensembl:   ENSG00000100749
Entrez:   7443
UniGene:   Hs.422662
Chromosome Mapping:   14q32

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