PrimePCR™ ddPCR™ Expression Probe Assay: KDELR3, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0050011; exonic

 
Fluorophore:   HEX
List Price:    $207.00
Your Price:   Log In
 

Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033511
Chromosome Location:   22:38877367-38877474question
Amplicon Length:   78

Gene Information

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal usually lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein and returns it to the ER. In yeast the sorting receptor encoded by a single gene ERD2 is a seven-transmembrane protein. Unlike yeast several human homologs of the ERD2 gene constituting the KDEL receptor gene family have been described. KDELR3 was the third member of the family to be identified and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing and encode different isoforms of KDELR3 receptor have been described. [provided by RefSeq Jul 2008]

Gene Symbol:   KDELR3
Gene Name:   KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Aliases:   ERD2L3
RefSeq:   NC_000022.10 NT_011520.12
Ensembl:   ENSG00000100196
Entrez:   11015
UniGene:   Hs.730819
Chromosome Mapping:   22q13.1

Number Description Download