PrimePCR™ ddPCR™ Expression Probe Assay: PGC, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0049957; exonic

 
Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033404
Chromosome Location:   6:41712443-41715015question
Amplicon Length:   76

Gene Information

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq Oct 2009]

Gene Symbol:   PGC
Gene Name:   progastricsin (pepsinogen C)
Aliases:   FLJ99563, PEPC, PGII
RefSeq:   NC_000006.11 NT_007592.15
Ensembl:   ENSG00000096088
Entrez:   5225
UniGene:   Hs.1867
Chromosome Mapping:   6p21.1

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