PrimePCR™ ddPCR™ Expression Probe Assay: PSME1, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049907; exonic

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033309
Chromosome Location:   14:24607930-24608043question
Amplicon Length:   84

Gene Information

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base which contains 6 ATPase subunits and 2 non-ATPase subunits and a lid which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome the immunoproteasome is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator referred to as the 11S regulator or PA28 that replaces the 19S regulator. Three subunits (alpha beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   PSME1
Gene Name:   proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Aliases:   IFI5111, MGC8628, PA28A, PA28alpha, REGalpha
RefSeq:   NC_000014.8 NT_026437.12
Ensembl:   ENSG00000092010
Entrez:   5720
UniGene:   Hs.75348
Chromosome Mapping:   14q11.2

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