PrimePCR™ ddPCR™ Expression Probe Assay: ACHE, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049818; exonic

Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5033155
Chromosome Location:   7:100490809-100490956question
Amplicon Length:   118

Gene Information

Acetylcholinesterase hydrolyzes the neurotransmitter acetylcholine at neuromuscular junctions and brain cholinergic synapses and thus terminates signal transmission. It is also found on the red blood cell membranes where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene and the structural diversity in the gene products arises from alternative mRNA splicing and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain muscle and other tissues is the hydrophilic species which forms disulfide-linked oligomers with collagenous or lipid-containing structural subunits. The other alternatively spliced form expressed primarily in the erythroid tissues differs at the C-terminal end and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq Jul 2008]

Gene Symbol:   ACHE
Gene Name:   acetylcholinesterase
Aliases:   ARACHE, N-ACHE, YT
RefSeq:   NC_000007.13 NG_007474.1 NT_007933.15
Ensembl:   ENSG00000087085
Entrez:   43
UniGene:   Hs.154495
Chromosome Mapping:   7q22

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