PrimePCR™ ddPCR™ Expression Probe Assay: PAK3, Human


ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   FAM; Same primer pair and probe as used in qPCR assay qHsaCEP0049659; exonic

Fluorophore:   FAM
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5032980
Chromosome Location:   X:110366314-110366423question
Amplicon Length:   80

Gene Information

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins a family of serine/threonine p21-activating kinases serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21) CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jul 2008]

Gene Symbol:   PAK3
Gene Name:   p21 protein (Cdc42/Rac)-activated kinase 3
Aliases:   CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK3
RefSeq:   NC_000023.10 NT_011651.17 NG_008288.1
Ensembl:   ENSG00000077264
Entrez:   5063
UniGene:   Hs.656789
Chromosome Mapping:   Xq23

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