PrimePCR™ ddPCR™ Expression Probe Assay: MAP2K3, Human

PrimePCR

ddPCR probe assay designed for gene expression analysis. Probe assays consist of unlabeled PCR primers and a dual labeled fluorescent probe.

Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0049317; exonic

 
Fluorophore:   HEX
List Price:    $207.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5032349
Chromosome Location:   17:21215461-21216817question
Amplicon Length:   117

Gene Information

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase which thus leads to the constitutive activation of MAPK14 and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq Jul 2008]

Gene Symbol:   MAP2K3
Gene Name:   mitogen-activated protein kinase kinase 3
Aliases:   MAPKK3, MEK3, MKK3, PRKMK3
RefSeq:   NC_000017.10 NT_010718.16
Ensembl:   ENSG00000034152
Entrez:   5606
UniGene:   Hs.514012
Chromosome Mapping:   17q11.2

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