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The Bio-Plex Pro RBM kidney toxicity assays, developed in partnership with Myriad RBM, comprise a highly relevant set of biomarkers for early detection and characterization of kidney toxicity/injury. Myriad RBM’s close collaboration with the Predictive Safety Testing Consortium (PSTC), FDA, and European Medicines Evaluation Agency (EMEA) was instrumental in the selection of markers found in these panels.
The assays are built on magnetic beads to enable robust quantification of multiple proteins in rat urine samples, providing valuable information throughout drug development — from lead optimization to preclinical and clinical protocol decision making. Assays are offered as premixed all-in-one kits for research involving:
Bio-Plex Pro RBM rat kidney toxicity assays are available as two panels and an albumin kit:
Based on 6.5 µm magnetic beads, these assay panels are compatible with both vacuum and magnetic wash stations. Magnetic washing simplifies plate processing, provides increased throughput, and results in decreased variability and increased reproducibility.
Premixed all-in-one kits
171-KTR1CK 1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 5 kidney toxicity markers in rat urine
171-KTR2CK 1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of 4 kidney toxicity markers in rat urine
171-KTR3CK 1 x 96-well, includes magnetic capture beads, detection antibodies, standards, controls, diluent, buffers, streptavidin-PE, flat bottom plate, and plate seals, for the detection of albumin in rat urine
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