The Seraclone™® ABO and Rh Grouping Reagents are monoclonal reagents intended for the determination of ABO and Rh antigens on human red blood cells. Seraclone Anti-A and Anti-A,B are capable of reacting with A1, A2, A3 and Ax subgroups. Seraclone Anti-B and Anti-A,B are capable of reacting with B and B weak subgroups. Seraclone ABO antisera do not react with cryptoantigens (T, Tn, and Tk activated).
The Seraclone Rh reagents for the detection of the D antigen include Anti-D Blend and Anti-D 226. Anti-D Blend is suitable for testing at the IAT phase to detect weak D antigens (Dweak or Dvariant including D VI). Anti-D 226 is not appropriate for use in the IATphase. Anti-D 226 does not detect D VI red blood cells.
Additional Seraclone Rh reagents include Anti-C, Anti-c, Anti-E and Anti-e. These antisera require only a five minute RT incubation.
The Seraclone ABO+Rh Control is a negative control that can be used with any of the Seraclone ABO/Rh reagents.