The Chiron® RIBA™ HCV 3.0 SIA is intended for use as a supplemental test for human serum or plasma specimens found to be repeatedly active in hepatitis C virus (HCV) antibody screening procedures. This test offers improved seroconversion sensitivity, demonstrating sensitivity early in 52 out of 86 seroconversion panels (30 percent) and high correlation with HCV RNA. In a study of 220 HCV RNA positive individuals, 99.5 percent were reactive using RIBA 3.0 SIA [Damen et al. Transfusion. 1995; 35(9):745–749].