CHT™ Ceramic Hydroxyapatite and Crystalline Hydroxyapatite Media

Advances in Separation & Purification: Purifying Monoclonal Antibodies

The affinity capture paradigm that dominates industrial IgG purification has proven unsuitable for IgMs because, in most cases, they are affected adversely by harsh elution conditions. The large size of IgMs is also a challenge because it limits the operating conditions and performance of traditional porous-particle-based chromatography media. This article describes how these challenges can be overcome with available technology to develop effective manufacturing procedures for IgM monoclonal antibodies.

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A Matrix With Unique Separation Properties and Unparalleled Selectivity and Resolution

CHT ceramic hydroxyapatite is a spherical, macroporous form of hydroxyapatite. The ceramic material overcomes many of the limitations of traditional crystalline hydroxyapatite and provides the throughput, stability, and reproducibility required for industrial biopharmaceutical manufacturing. It has unique separation properties and unparalleled selectivity and resolution.

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